Veterinarians seek permission to research pot meds for pets

AP

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  • In this Monday, Oct. 30, 2017, photo, Luke Byerly tends to his 14-year-old beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. Byerly is using CBD, a non-psychoactive component of marijuana, oil to treat the dog's arthritis. (AP Photo/David Zalubowski)

  • 1

    In this Sept. 29, 2017 photo, Dr. Byron Maas poses in the Bend Veterinary Clinic, which offers products with marijuana ingredients for ailing dogs, in Bend, Ore. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana, even though there's little evidence they actually work, or whether there might be harmful side effects. (AP Photo/Andrew Selsky)

  • 2

    In this Sept. 29, 2017 photo, marijuana products for dogs are lined up on a shelf in the Bend Veterinary Clinic in Bend, Ore. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana, even though there's little evidence they actually work, or whether there might be harmful side effects. (AP Photo/Andrew Selsky)

  • 3

    In this Monday, Nov. 6, 2017, photo, a syringe loaded with a dose of CBD oil is shown in a research laboratory at Colorado State University in Fort Collins, Colo. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 4

    In this Monday, Nov. 6, 2017, photo, research technician Kelsie Condon walks a Golden Retriever named Zach on a treadmill to determine if the dog has arthritis and can be enrolled in a study involving the use of CBD oil at Colorado State University in Fort Collins, Colo. Two researchers at the school are running trial studies to see if using marijuana extract aids in the treatment of dogs with epilepsy as well as arthritis. (AP Photo/David Zalubowski)

  • 5

    In this Monday, Nov. 6, 2017, photo, a sculpture stands outside the front door of the veterinary school at Colorado State University in Fort Collins, Colo. Two researchers at the school are leading efforts to determine the efficacy of using CBD oil in the treatment of dogs with epilepsy and arthritis. (AP Photo/David Zalubowski)

  • 6

    In this Monday, Nov. 6, 2017, photo, Dr. Stephanie McGrath checks over the scan of a dog enrolled in a study that she is leading to see the efficacy of CBD oil in the treating of dogs with epilepsy at Colorado State University in Fort Collins, Colo. McGrath said she hopes the results will be a stepping stone for longer and more diverse studies, and that they provide useful information for human medicine. (AP Photo/David Zalubowski)

  • 7

    In this Monday, Nov. 6, 2017, photo, Dr. Stephanie McGrath talks about a study that she is leading to determine the efficacy of using CBD oil in the treatment of dogs with epilepsy at Colorado State University in Fort Collins, Colo. McGrath said she hopes the results will be a stepping stone for longer and more diverse studies, and that they provide useful information for human medicine. (AP Photo/David Zalubowski)

  • 8

    In this Monday, Oct. 30, 2017, photo, Luke Byerly administers CBD oil on the dinner for his beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 9

    In this Monday, Oct. 30, 2017, photo, a bottle of CBD oil sits on a counter after Luke Byerly administered a dose of the liquid to his 14-year-old beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 10

    In this Monday, Oct. 30, 2017, photo, Luke Byerly guides his 14-year-old beagle, Robbie, as the dog eats his food treated with CBD oil during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • In this Monday, Oct. 30, 2017, photo, Luke Byerly tends to his 14-year-old beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. Byerly is using CBD, a non-psychoactive component of marijuana, oil to treat the dog's arthritis. (AP Photo/David Zalubowski)

  • 1

    In this Sept. 29, 2017 photo, Dr. Byron Maas poses in the Bend Veterinary Clinic, which offers products with marijuana ingredients for ailing dogs, in Bend, Ore. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana, even though there's little evidence they actually work, or whether there might be harmful side effects. (AP Photo/Andrew Selsky)

  • 2

    In this Sept. 29, 2017 photo, marijuana products for dogs are lined up on a shelf in the Bend Veterinary Clinic in Bend, Ore. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana, even though there's little evidence they actually work, or whether there might be harmful side effects. (AP Photo/Andrew Selsky)

  • 3

    In this Monday, Nov. 6, 2017, photo, a syringe loaded with a dose of CBD oil is shown in a research laboratory at Colorado State University in Fort Collins, Colo. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 4

    In this Monday, Nov. 6, 2017, photo, research technician Kelsie Condon walks a Golden Retriever named Zach on a treadmill to determine if the dog has arthritis and can be enrolled in a study involving the use of CBD oil at Colorado State University in Fort Collins, Colo. Two researchers at the school are running trial studies to see if using marijuana extract aids in the treatment of dogs with epilepsy as well as arthritis. (AP Photo/David Zalubowski)

  • 5

    In this Monday, Nov. 6, 2017, photo, a sculpture stands outside the front door of the veterinary school at Colorado State University in Fort Collins, Colo. Two researchers at the school are leading efforts to determine the efficacy of using CBD oil in the treatment of dogs with epilepsy and arthritis. (AP Photo/David Zalubowski)

  • 6

    In this Monday, Nov. 6, 2017, photo, Dr. Stephanie McGrath checks over the scan of a dog enrolled in a study that she is leading to see the efficacy of CBD oil in the treating of dogs with epilepsy at Colorado State University in Fort Collins, Colo. McGrath said she hopes the results will be a stepping stone for longer and more diverse studies, and that they provide useful information for human medicine. (AP Photo/David Zalubowski)

  • 7

    In this Monday, Nov. 6, 2017, photo, Dr. Stephanie McGrath talks about a study that she is leading to determine the efficacy of using CBD oil in the treatment of dogs with epilepsy at Colorado State University in Fort Collins, Colo. McGrath said she hopes the results will be a stepping stone for longer and more diverse studies, and that they provide useful information for human medicine. (AP Photo/David Zalubowski)

  • 8

    In this Monday, Oct. 30, 2017, photo, Luke Byerly administers CBD oil on the dinner for his beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 9

    In this Monday, Oct. 30, 2017, photo, a bottle of CBD oil sits on a counter after Luke Byerly administered a dose of the liquid to his 14-year-old beagle, Robbie, during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

  • 10

    In this Monday, Oct. 30, 2017, photo, Luke Byerly guides his 14-year-old beagle, Robbie, as the dog eats his food treated with CBD oil during a break at Byerly's job as a technician at a veterinary clinic in east Denver. People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. (AP Photo/David Zalubowski)

BEND, Ore. (AP) Dr. Byron Maas surveys a supply of marijuana products for dogs that lines a shelf in his veterinary clinic. They're selling well.

"The 'Up and Moving' is for joints and for pain," he explains. "The 'Calm and Quiet' is for real anxious dogs, to take away that anxiety."

People anxious to relieve suffering in their pets are increasingly turning to oils and powders that contain CBDs, a non-psychoactive component of marijuana. But there's little data on whether they work, or if they have harmful side effects.

That's because Washington has been standing in the way of clinical trials, veterinarians and researchers say. Now, a push is underway to have barriers removed, so both pets and people can benefit.

Those barriers have had more than just a chilling effect.

When the federal Drug Enforcement Administration announced last year that even marijuana extracts with CBD and little or no THC - marijuana's intoxicating component - are an illegal Schedule 1 drug, the University of Pennsylvania halted its clinical trials. Colorado State University is pushing ahead.

The U.S. Food and Drug Administration has warned companies that sell marijuana products online and via pet shops and animal hospitals that they're violating laws by offering "unapproved new animal drugs." The FDA threatened legal action.

But, seeing potential benefits of CBDs, the American Veterinary Medical Association's policy-making body said last summer it wants the DEA to declassify marijuana as a Schedule 1 drug "to facilitate research opportunities for veterinary and human medical uses." It asked the board of the national veterinarians' organization to investigate working with other stakeholders toward that goal. The board is awaiting a recommendation from two group councils.

"The concern our membership has is worry about people extrapolating their own dosages, looking to medicate their pets outside the realm of the medical professional," Board Chairman Michael Whitehair said in a telephone interview. "This is an important reason for us to continue the research."

Utah Sen. Orrin Hatch, a conservative Republican, became an unlikely champion of this push when he introduced a bill in September that would open the path for more clinical research. While Hatch said he opposes recreational marijuana use, he wants marijuana-based drugs, regulated by the FDA, produced for people with disorders.

"We lack the science to support use of medical marijuana products like CBD oils, not because researchers are unwilling to do the work, but because of bureaucratic red tape and over-regulation," Hatch said.

Dawn Boothe, of Auburn University's College of Veterinary Medicine, is waiting for federal approval to begin a study of marijuana's effects on dogs with epilepsy. The classification of marijuana products containing CBD as a Schedule 1 drug, the same category as heroin and LSD, creates a "major, major, major, terrible roadblock" for researchers, Boothe said in a phone interview.

Researchers at the University of Pennsylvania School of Veterinary Medicine were studying CBDs' effects on dogs with osteoarthritis and pruritis, or itchiness, until the DEA released its policy statement.

"The ambiguity in this process has really brought us to a screeching halt," said Michael DiGregorio, director of the university's clinical trials center. "It is research that needs to be done, because there are a lot of CBD products out there."

When it clarified that marijuana CBD extracts are Schedule 1 drugs, the DEA said it was assigning a code number to those substances to better track them and to comply with international drug control treaties.

DiGregorio complained that researchers seeking federal approval to study CBD products are told to provide certain data, but that data isn't normally available until the study is done.

"If you don't have the data, you can't get the registration to do the work," he said.

On a recent morning, Maas took a break from seeing four-legged patients in the Bend Veterinary Clinic. A stethoscope dangling from his neck over green scrubs, Maas said his clients have reported CBDs help relieve pain, arthritis, anxiety, loss of appetite, epilepsy and inflammation in their pets.

"Unfortunately there's not a lot of research out there, especially on animals, on CBD compounds," Maas said. "The research is really necessary to help us understand how to actually use these compounds on our pets."

Veterinarian Janet Ladyga of the Blue Sky Veterinary Clinic, also in Bend, said she doesn't recommend marijuana products because of the unknowns.

"We don't have a lot of evidence right now, so we don't know the toxicity or the safety profile ... and we don't have any good evidence to show either if it's safe or efficacious," she said.

The study at Colorado State University aims to provide some data. The roughly two dozen dogs in the arthritis study and the 30 in the epilepsy tests are given either CBD oil or a placebo. For the arthritis study, activity monitors are attached to the animals' collars, to determine if they're more mobile when they're taking CBD.

Principal investigator Stephanie McGrath said she hopes the results will be a stepping stone for longer and more diverse studies, and that they provide useful information for human medicine.

"Every medication we're taking has been given to a dog first," the University of Pennsylvania's DiGregorio noted.

Meanwhile, Boothe said she had everything ready to start her study in January, and was waiting for a green light from federal officials.

"I don't know what's taking so long," she said.

___

Follow Andrew Selsky on Twitter at https://twitter.com/andrewselsky

         

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